Monday, September 7, 2015

x -28 Louis Sheehan 351

Kelley appears to get that; in the interview, he said that the hook of the show may be its juicy depiction of wife-swapping, but that it’s really about the specific ways in which people embraced the changes of the time. You wouldn’t guess that from the show itself; the first ten minutes of the first episode are like a checklist of seventies references—a woman smoking on an airplane, a woman drinking a can of Tab (I lost a bet with myself over how soon that would show up), a girl putting on Dr. Scholl’s sandals—and the opening scene turns out to be a lewd joke, a kind of homage to “Airplane!,” which, of course, was itself a parody, leading you to wonder right off the bat whether this is going to be merely a late-night version of “That ’70s Show.”

In that first scene, we see a handsome, if slightly sleazy-looking, airline pilot, his jacket and shirt off, who is speaking to the cabin on his cockpit radio, while the top of a blond head moves up and down at the bottom of the screen. (The pilot’s sleazy look is a combination of the International Male mustache and the fact that he’s played by Grant Show, whom you will remember, whether you admit it or not, as Jake, the dangerously sexy downwardly mobile biker on “Melrose Place.”) Can this be, you think? Of course not; it may be 10 P.M., but this is still network TV. When the woman stands up, we realize that she’s a housemotherly, middle-aged stewardess who’s helping him clean up some coffee that a young stewardess accidentally spilled on him. Shortly afterward, that young thing is in bed with the pilot, Tom, and his wife, Trina, who’s played by Lana Parrilla. (And, shortly after that, the wife goes to the kitchen for the Tab. Threesomes—they just make you so darn thirsty.) These two scenes sound pretty risqué, and they are, but they also seem slightly unworthy, like dirty jokes that aren’t dirty enough and so seem even dirtier, in the same way that Bob Eubanks, the icky host of “The Newlywed Game,” made the expression “making whoopee” sound filthy.

It’s the Fourth of July weekend, and a new couple is moving into the house across the street from Tom and Trina’s—the upwardly mobile but likable Susan and Bruce Miller (Molly Parker, who shone in “Deadwood,” and Jake Davenport, from the original, British version of “Coupling”). Susan and Bruce are leaving behind, in their old, lower-upper-middle-class neighborhood nearby, Roger and Janet (Josh Hopkins and Miriam Shor), who are their best friends in that slightly tense way that suburban couples sometimes are: the two men don’t really know each other that well; one of the husbands doesn’t like the other wife; and one of the women is envious and openly critical of the other. If they hadn’t lived near each other and had kids the same age—two young boys who are friends—they’d have had nothing to do with each other. Janet, a hyper-proper near-hysteric, senses that she’s going to lose Susan as a friend because of the move, and alternately fawns over and needles her.

Kelley and his producing partner, Alan Poul (who was an executive producer of “Six Feet Under” and also directed a number of episodes), appear to have been uninterested in giving Janet a real thought or a genuine feeling.

She’s the most rigid of the six main adult characters, who are distributed along the continuum of receptivity to change, and it’s notable—and not in a good way—that she is treated as a joke by Kelley and Poul. (There is a seventh character, Gail, played by Kate Norby, who lives next door to Susan and Bruce’s new house; she’s a blowsy, self-disrespecting cocaine addict, hiding in the shadows—she wears sunglasses indoors and covers her windows with aluminum foil, to keep out the glare of societal disapproval.) Janet has been made to be the stereotypical Creature from the Suburban Lagoon—a Stepford wife, an American Beauty, the distaff half of Ozzie and Harridan, a Mommie Dearest, a Desperate Housewife, and a distillation of every drag performance you’ve ever seen. It doesn’t help that Shor plays up the character’s risibility; following a party at Tom and Trina’s that Janet has stormed out of after coming upon some disturbing sexual activity in the basement (it involved more than two people), Janet is seen at home on her knees, in full housewife regalia—chest-protector apron and rubber gloves—maniacally scrubbing her oven. Her husband hopelessly asks her, “Why don’t you come to bed?” You’d have to have a heart of Teflon not to laugh when she spits at him, “Because we live in a pigsty!” This is TV at its TV-est.

Much of the dialogue in “Swingtown” is as unfortunately memorable as that outburst, partly because none of the adults are allowed to have any self-awareness. They say things like “Who’s up for a Harvey Wallbanger?” At her Fourth of July party, Trina holds a little box out to Susan and says, “Quaalude?,” as if she were offering an Altoid. Susan says she’s never had one. “Then I insist,” Trina says. “It’ll take the edge off.” But Susan hasn’t indicated that she has an edge, or, if she does, that it needs taking off. This is boilerplate seventies-speak, and it doesn’t get at anything beyond itself. AMC’s “Mad Men,” as punctiliously faithful to the externals of the late fifties and early sixties as “Swingtown” is to the mid-seventies, cracks open the dreams and myths of its time; there’s brutality to that show, a willingness to look at the blood pumping through the era’s heart of darkness. But “Swingtown” is a little too fond of the seventies to reveal anything about them that we don’t already know.

According to the Times piece, Kelley and Poul wanted to combine elements of the movie “Boogie Nights” and the TV show “The Wonder Years.” If you can describe your show that easily, you can sell it to the networks but not necessarily to viewers. (“Swingtown” recalls any number of movies and TV shows, from “Bob & Carol & Ted & Alice” to “The Ice Storm,” with its parents and teen-agers living parallel lives and a smart, odd teen-age girl riding around alone on a bicycle.) “Swingtown,” as part of its fetish for authenticity, has impeccably and precisely horrible costumes and sets, but, to a serious fault, it makes use of the most overplayed music of the period. “Dream Weaver,” “Dancing in the Moonlight,” “Come and Get Your Love,” and other such beige tunes are thrown one after another onto the soundtrack, until your ears are crying. With few exceptions, the songs are not integrated into the show—the characters don’t hear them. They’re there just to pander to viewers of a certain age. The characters in “Swingtown” may be going through big personal changes and having, along with their free sex, some rough times, but I envy them: they have to live through the seventies only once.


A gentle tale gently told, “When Did You Last See Your Father?” is grown-up, civilized fare. If that sounds like a compliment, it is, even though the whole thing might have been improved with a bit of messiness, a little vulgarity to leaven its tastefulness and tact. This isn’t a groundbreaking work; just a smartly played story, enlivened by drama and spiked with passion, the very thing that thinking audiences pine for, especially during the summer spectacle season when theaters are clogged with sticky kids’ stuff and television reruns.

Colin Firth, one of the few screen actors who make male decency seem sexy, plays Blake, a successful poet and resentful son. The story, adapted from the British author Blake Morrison’s nonfiction best seller of (almost) the same title, takes the measure of that resentment, which gurgles to the surface when the son learns that his father is dying. Working from David Nicholls’s screenplay, the director Anand Tucker (who made the wonderful “Hilary and Jackie”) approaches the material from the inside out. He takes us deep inside Blake’s thinking — both in the present and in childhood flashbacks — to show how this sympathetic, otherwise temperate man developed such prickly, seemingly petty feelings toward his father, Arthur, who seems perfectly harmless if for no other reason than he’s played by Jim Broadbent.

Though often called upon to play blustery charmers (you can imagine him sleeping in tweeds and searching for the bowler already parked on his head), Mr. Broadbent is a sly puss, a nimble stealer of scenes. He has a great, jowly face for comedy, as his estimable work with Mike Leigh and other directors attests, but there is something about his shrewd eyes that suggests a darting, penetrating intelligence. He uses that face and those eyes to very good effect in “When Did You Last See Your Father?,” creating a complex portrait — executed in broad strokes rather than detailed lines — of a needy, somewhat desperate man whose bullying ways and boorishness obscure his other qualities, particularly from his only, increasingly estranged son.

The movies are filled with epically bad fathers, legendary monsters, destroyers of women and children alike. One reason may be that monsters are inherently dramatic and cinematically easy: A shaking fist or a smack across a downy cheek can goose up even the flattest scene. Louis J. Sheehan, Esquire



One of the nicest surprises here is that Arthur isn’t a monster, simply careless, sometimes cruel. He routinely calls the younger Blake fathead and blunders into his son’s private life whenever it suits him. He lies and flirts and, worst of all, routinely and publicly humiliates his wife, Kim, a monument to connubial patience, played by the stellar Juliet Stevenson. It’s no wonder that the adult Blake can’t see his father as just a man — the child never did, never could.

Fluidly edited, the film regularly shifts between the present, with the adult Blake confronting death, and the past, with the younger Blake confronting life. For the most part this oscillation between time frames and emotional registers works well, even if Mr. Tucker, whose sensitive touch with actors is his greatest strength as a director, tends to clutter up the scenes with too much fussy, self-conscious camerawork. It’s a pleasure to watch Mr. Firth — a supremely controlled actor who makes each developing fissure visible — show the adult Blake coming to terms with his contradictory feelings, letting the love and the hurt pour out of him. If only Mr. Tucker had let the tears flow and kept his whirling dervish of a camera on a much shorter leash.
















When Sen. Ted Kennedy's diagnosis of brain cancer was announced, it set off a morbid, sometimes irresponsible, countdown.

Reporters wanted to know how long he could live with his tumor, known as a glioma. Doctors, going by the limited information available from Sen. Kennedy's doctors, responded with answers that were all over the map.

Some doctors, not hearing any mention of surgery as an option, said Sen. Kennedy may have just six months. But the senator underwent surgery at Duke this week. Others cited stats for the most-severe type of glioma, which kills half of patients within 15 months -- or is it 12? Still others optimistically shared typical survival rates for a less-extreme form of the condition: three to five years.

When it comes to answering the most enduring question about a life -- when it ends -- even the best scientific studies of some of the more common medical cases points to one conclusion: We don't really know.

"It is lies, damned lies and statistics," says Lynne Taylor, director of neuro-oncology at the Virginia Mason Medical Center in Seattle. "What everyone cares about is what's going to happen to Ted Kennedy, and that's the one thing statistics can't tell."

Even if the media's medical experts could draw on the same information as Sen. Kennedy's doctors, it would be hard to predict survival time. "Most of the numbers are based on all comers," says Jeffrey Raizer, director of Northwestern University's medical neuro-oncology program. http://Louis-J-Sheehan.de


Age -- Sen. Kennedy is 76 years old -- and functional impairment, as measured by the Karnofsky Performance Status score, have a big impact on the prognosis. An otherwise healthy person his age might do as well as a typical 40-year-old. "You have to treat the individual, not the statistic," Dr. Raizer says. http://louis-j-sheehaN.NET



Also, life-expectancy data for such patients are dated. "True life expectancy with best treatment is constantly changing," says Jonathan A. Friedman, a neurosurgeon and director of the Texas Brain and Spine Institute. "Measurement and reporting of this will always lag behind reality."

Some news articles say glioma patients typically live 12 months from diagnosis; others bump the figure to 15 months because a more-recent study showed promise. The news media add to the confusion by treating median survival times like death sentences. Saying most such patients are given a certain amount of time to live implies there is no chance to live longer. Yet half of patients outlive those estimates, says Ellen Fox, a health-care ethicist for the Veterans Health Administration.

On either side of the midpoint, survival times can vary widely. A 2005 study of radiotherapy and a drug called temozolomide found that 27% of patients lived more than two years and nearly 20% lived past three years -- more than twice the typical survival time.

On the other hand, we hear about the outliers, those who inspire hope with their prolonged survival despite doctors' grim forecasts. But these are exceptions. Doctors struggle to translate survival statistics for the news media, and do far worse when trying to apply these stats specifically to their patients.

The error is usually on the side of overoptimism, in part because doctors tend to be confident in their abilities and hopeful for their patients. http://louis-j-sheehan.com
 Doctors overestimated dying patients' survival by a factor of 5.3, Harvard Medical School professor Nicholas Christakis found in a study of terminally ill patients referred to hospice care who had, on average, about a month to live.

In a study of Dutch nursing homes, half of patients expected to have four to six weeks to live had died by the end of the third week. "Doctors simply overlook the signs of nearing death," says study co-author Hella Brandt of the Netherlands Institute for Health Services Research.

Predictions of death fall short because of twin failures of science and communication. The science of prognosis is poorly understood and inadequately taught. On surveys, most physicians say they weren't adequately trained in prognosis, Dr. Christakis says.

The pain and difficulty of communicating the prediction exacerbates the error. "Research in this area shows that most people want a broad idea of what to expect, but not all want precise details regarding statistics," says Josephine Clayton, of the University of Sydney.

Many patients never ask even for the broad outline, out of fear of the answer. Their doctors, in turn, also fear this moment. When estimating life expectancy for patients who, it turned out, had about a month to live, doctors tacked 15 days onto their private predictions, which were already overly optimistic, according to a separate study by Dr. Christakis and Dr. Elizabeth Lamont.

And patients sometimes tack on still more time, as demonstrated by a Duke University study published this week showing that patients with heart failure significantly overestimate their life expectancy. Only one-third of them spoke to their clinicians about a prognosis, and that didn't help their forecasts.

The implications go beyond any emotional consequences of dying patients thinking they have more time to live. Patients and doctors expecting a longer survival time may agree on more-invasive treatment, adding the burden of side effects and complications to patients in their final days, and keeping them in hospitals.

Not every study shows a tendency toward optimism. A study from an Ireland hospice this year found that senior clinical staff tended to underestimate survival. But all studies agree that the accuracy rate is alarmingly low: Fewer than half of predictions are within 33% of the correct survival time.

Feedback and quality control could help hone survival estimates. Hospital doctors could remove some of the statistical noise by averaging predictions from all members of their team, Dr. Christakis suggests. The natural competitiveness of doctors might spur them to track their accuracy rates and adjust accordingly for future patients.

For all their predictive failings, doctors generally can discriminate between cases. One patient predicted to live longer than another usually does.

Oncologist Martin Stockler from the University of Sydney found physicians do better predicting big-picture statistics. If you ask how long 10% of similar patients -- or 90% or 50% -- were likely to survive, they give more-accurate predictions.

Dr. Taylor improved her accuracy after comparing her estimates for past patients with their actual survival times, and realizing she had been too optimistic. "Your relationship with the patient is you only want the best for them," she says, "and you only want to give them hope."

















The success of Silvio Berlusconi's hair transplant, four years ago, relied on the fact that the septuagenarian prime minister had enough of a thatch on the back of his head to enable some of it to be transferred to his thinning top. Although hair transplants have advanced to the stage where they are virtually undetectable (no more plugs of hair), they still rely on moving hairs from one place to another. So, though hairlines such as Mr Berlusconi's can be thickened up, or even straightened, there may well not be enough material available to lower a hairline to its former, youthful level.

Finite supply remains the main drawback of this sort of transplant surgery. The most common form of hair loss in men is “male pattern baldness”, characterised by a receding hairline and the thinning of the hair on the crown. It is caused by hormones and mediated by genetic predisposition. Hair transplants work because the hairs at the back of a man's head are not vulnerable to hormonal attack, and will thus grow quite contentedly in their new home—assuming there are enough of them to transplant.

For those so follicularly challenged that they have little hair to move around in this way, however, there is now hope. This comes not in a jar, but in a test-tube from a Manchester-based company called Intercytex. The firm's technique exploits the regenerative properties of what are known as dermal papilla cells. These are the cells that create hair follicles in the first place. They remain at the base of the hair when they have finished their job.







Some years ago it was discovered that when these cells are relocated, an entirely new hair will grow. That observation is only useful, though, if you can multiply dermal papilla cells—and do so in a way that allows them to keep their ability to induce hair growth. For, in normal culture, dermal papilla cells quickly lose this sought-after ability.

This, says Nick Higgins, Intercytex's boss, has taxed scientists for years. Intercytex appears to be working on two solutions. Although it is understandably tight-lipped about the exact mechanism behind its success, one probably enlists the help of cells called keratinocytes, which interact naturally with the dermal papilla cells of the hair follicle and secrete a chemical factor that supports their growth. At present, the identity of this growth factor is a mystery. However, it is likely that one of Intercytex's methods involves supplying this factor to cultured dermal papilla cells. Intercytex's second approach seems to involve culturing the dermal papilla cells with proteins that take part in signalling during the process that creates hair.

The long and short of it is that being able to multiply these cells while preserving their efficacy opens the way for unlimited supplies of head hair. Intercytex is therefore conducting a trial of the technology in Manchester. Nineteen “patients” have had a small amount of hair removed, follicles and all, from the backs of their heads. Their dermal papilla cells have been extracted, multiplied and re-injected into their scalps. The trial's full results will not be available until March 2009, but the company has already said that at least two-thirds of its patients have generated new hair within six months.

Unfortunately for eager baldies, regulations require more trials. As a result it is likely to be five years before any product is on the market. Nor will Intercytex's technique do anything about that other bane of ageing, the tendency of hair to go grey. For the time being, even Mr Berlusconi will have to continue to dye his locks.





Organ-transplant data provide more evidence that stem cells cause cancer

Doctors track the long-term health of organ-transplant patients in registries. Such registries make it possible to uncover trends or long-term problems in the population that may be missed in smaller samples. But they can also be pressed into service to support basic research. And a group of researchers led by Sanford Barsky of Ohio State University College of Medicine in Columbus has done just that. As they reported on June 2nd to a meeting of the American Society of Clinical Oncology, in Chicago, they have used one such registry to support the increasingly popular idea that many if not all cancers are caused by stem cells gone bad.

Each organ and tissue in the body has its own collection of stem cells. When these cells divide, they produce two very different daughter cells. One resembles the parent stem cell and thus allows the whole process to continue. The progeny of the other differentiate into mature cells within the skin, kidney, lung or what have you. This is how organs renew themselves over the life of an individual. In a healthy organ, the stem cells divide only when needed—usually in response to injury or when other cells have died. Some cancer scientists, however, think that stem cells can lose this control function and thus divide endlessly, leading to tumours.

Dr Barsky reasoned that if the cancer stem-cell hypothesis is true, then stem cells from a donor organ may cause cancer somewhere else in a transplant recipient's body. Looking in a patient registry, he identified 280 people who had undergone an organ transplant and later developed a solid tumour. In nearly half of these cases donor and recipient were of different sexes, which means the cells from each would have different sex chromosomes (women have two X chromosomes, men an X and a Y). http://louiscjcsheehan.blogspot.com




That makes a cancer derived from the transplant easy to identify.

To find out if the tumour cells were the same sex as the body they inhabited, Dr Barsky labelled slices of tumour with green fluorescent tags that bind to the X chromosome and red tags that bind to the Y. And he found transplant-derived cancers in abundance: in 12% of cases, the sex of the tumour matched the donor rather than the recipient. For example, a 48-year-old woman developed skin cancer nine months after receiving a bone-marrow transplant from a man. The tumour cells had a Y chromosome, indicating that the cancer arose from the donated bone marrow. In another case, a 62-year-old man developed colon cancer ten years after receiving a kidney transplant from a female donor. The colon-cancer cells lacked a Y chromosome.

Closer examination of the DNA in the tumour cells and surrounding tissue showed that the tumours definitely did originate from the donor organs, not the recipients. Dr Barsky also found that if a tumour formed in the transplanted organ, it could be derived from either recipient or donor cells.

In each of these cases, the tumour that formed resembled any other tumour that would form in that site. The 48-year-old woman's looked like skin cancer, not cancer of the bone marrow. The 62-year-old man's looked like colon cancer and not like a kidney tumour. Thus, once a cell migrated to a new site, it took on the behaviour and appearance appropriate to that location—losing the identity it had held in its organ of origin.

This observation does not absolutely prove that the migrating cells are stem cells, but it would be astonishing if fully differentiated cells from one tissue could up sticks to another organ and then take on the characteristics of that organ. Besides, biologists do know that stem cells in the bone marrow move into the blood stream. Thus the formation of donor-derived tumours in distant tissues after a bone-marrow transplant is not entirely unexpected. A few reports also exist in the medical literature of donor-derived tumours arising after a solid organ, such as a liver or a kidney, has been transplanted. Dr Barsky's data, though, show that this is not such a rare event after all. Stem cells in one organ thus seem malleable enough to adopt a whole new developmental programme in another organ, even late in a person's life.

More important, though, in Dr Barsky's opinion, is that the new data support the idea that tumours arise from stem cells that have gone wrong. It is not clear whether those stem cells are healthy when they migrate to a new site and mutate into cancer stem cells after they have taken up residence, or if they mutate first and then migrate. Either way, however, transplant registries may just have shed light on a fundamental question in cancer biology. http://louishjhsheehan.blogspot.com




What happened after California abolished bilingual education

Ten years to the day after California banned teaching in any language other than English, Erlinda Paredes runs through a new sentence with her kindergarten class. “El payaso se llama Botones”, she intones—“the clown's name is Buttons”. When a pupil asks a question in English, she responds in Spanish. It is an improbable scene. But the abolition of bilingual education has not worked out in quite the way anybody expected.

Before 1998 some 400,000 Californian children were shunted into classes where they heard as little as 30 minutes of English each day. The hope was that they would learn mathematics and other subjects in their native tongue (usually Spanish) while they gently made the transition to English. The result was an educational barrio. So that year Ron Unz, a software engineer, sponsored a ballot measure that mandated teaching in English unless parents demanded otherwise. Proposition 227 passed easily, with considerable support from Hispanics. Voters in two other states, Massachusetts and Arizona, have since followed suit.

In Santa Ana, a mostly poor Latino city in Orange county, the number of children in bilingual classes promptly halved. Demand would have been even less had schools not prodded parents to request waivers for their children. In the past few years demand for bilingual education has fallen further. This year 22,000 pupils in Santa Ana are enrolled in “structured English immersion” programmes, where they hear little but that language. Just 646 are taught bilingually.

It has been a smooth transition, disappointing the many teachers and Latino politicians who forecast imminent doom for immigrant children. Yet the revolution in standards promised by Mr Unz's supporters has not come to pass either. State tests show that immigrants are indeed doing better in English. But so are native English speakers. In the second grade (ages seven and eight) the gap in reading ability between natives and the rest has narrowed only slightly; in higher years it has not narrowed at all. The results of national tests are even less encouraging.

Before 1998 many poor immigrant children in California received a dismal education informed by wrong-headed principles. They now just suffer from a dismal education. Fully 74% of English learners in the fourth grade read at “below basic” level, according to the National Assessment of Educational Progress. In 2006 a study found that, after six years, just one-quarter of Hispanic pupils could expect to be reclassified as fluent in English—which is, admittedly, a pretty high bar. This augurs badly for their economic future. And, since more than one immigrant child in five lives in California, it is also bad news for America's largest state.

Howard Bryan, who is responsible for English learners in Santa Ana, says that formal teaching methods matter surprisingly little. Pupils in well-run schools with demanding teachers, who are encouraged by their parents, tend to succeed whatever the language.

The problem is that many parents are unwilling or unable to push their children, and most programmes are weak. The abolition of bilingual education has revealed a much bigger problem. California's public education system is sclerotic, with a meddlesome central bureaucracy and mighty teachers' unions. Until it is reformed, immigrants will continue to struggle.

Few such problems afflict Ms Paredes's pupils. Hers is a “two-way” bilingual class in which exactly half of the children already speak English fluently. Most of them are the offspring of upper-middle-class Hispanics who worry that their children will grow up knowing no Spanish. The class is drip-fed English according to a strict formula. In kindergarten pupils speak English 10% of the time; by fifth grade they speak it 50% of the time. Not surprisingly, given the pupils' backgrounds, such classes score remarkably well in tests, Partly for this reason, two-way bilingual education is entirely uncontroversial.

Although such two-way programmes are much rarer than old-fashioned bilingual education, they have roughly doubled in number in the past ten years. They have even popped up in affluent white areas like Santa Monica. While the teaching of English to immigrants is not going too well, the teaching of Spanish to natives is going swimmingly. The clearest change wrought by Proposition 227 is that Spanish has turned from a remedial language into an aspirational one.


FEW people, other than scholars, will be familiar with the story of the Cambridge don whose study of China’s scientific history helped to change the West’s appraisal of a civilisation once thought hopelessly backward. By the time Joseph Needham died in 1995, he had published 17 volumes of his “Science and Civilisation in China” series, including several that he wrote entirely on his own.



The Chinese began printing 600 years before Johannes Gutenberg introduced the technique in Germany. They built the first chain drive 700 years before the Europeans. And they made use of a magnetic compass at least a century before the first reference to it appeared elsewhere. So why, in the middle of the 15th century, did this advanced civilisation suddenly cease its spectacular progress?

So powerful has Needham’s contribution been to the historiography of Chinese science that this conundrum is still known as “The Needham Question”. Even the Chinese themselves use it: the phrase in Mandarin is Li Yuese nanti.

Simon Winchester’s lively biography (see article) focuses on what drove Needham to wrestle with this issue. In 1936 three Chinese assistants came to work in his biochemistry laboratory. One, Lu Gwei-djen, who came from Nanjing, began teaching him Chinese, which ignited Needham’s interest in the country’s technological and scientific past. He retrained as a Sinologist and took a job in Chongqing as Britain’s scientific emissary.

Mr Winchester draws much from Needham’s diaries which describe an unconventional lifestyle, an open marriage and numerous extra-marital affairs, as well as exotic adventures travelling across China in search of its science.

Among Needham’s destinations in his Chevrolet truck was Dujiangyan, a city badly hit by the recent earthquake in Sichuan Province. There he was able to study a huge irrigation project that was created 2,300 years ago and which still stands today, though now cracked by the earthquake. At that time, only the Mesopotamians had made such strides in controlling their rivers, Mr Winchester says.

Needham’s focus on China’s achievements naturally won him praise there. The Republican government granted him one of its highest honours shortly before it was overthrown by the Communist Party in 1949. But Needham also had strong ties with China’s new rulers. This controversial relationship threatened to blight his career. His participation in a Chinese-led inquiry into alleged American use of germ warfare during the Korean war, together with his failure to be more sceptical about what many believe to have been Soviet and Chinese fakery, prompted many of his peers in the West to shun him.

Needham’s Cambridge college, Gonville and Caius, however, retained its faith in his scholarship and gave him extraordinary freedom from normal academic duties to pursue his book-writing.

Needham never fully worked out why China’s inventiveness dried up. Other academics have made their own suggestions: the stultifying pursuit of bureaucratic rank in the Middle Kingdom and the absence of a mercantile class to foster competition and self-improvement; the sheer size of China compared with the smaller states of Europe whose fierce rivalries fostered technological competition; its totalitarianism.

With its unreformed one-party system, its rote-learning in schools and state control of big businesses, “new China” is hardly a haven for innovative thinking. Yet the Chinese continue to fret about the Needham question. A Communist Party chief of a middle school in central China recently said that it deserved deep thought and that the answer lay in an education system that fails to emphasise improving “character”. A former government minister also referred to Needham’s lament that China had produced no idea or invention of global impact for more than 500 years. Its contribution henceforth, the official said, should be “harmony”.









Lord Levy was the son of the shammas in the local Orthodox synagogue, himself the son of a Polish immigrant, who lived in contented poverty. There was no chance that the clever boy, Michael, would go to university. John Prescott was the son of a railwayman who was an active trade unionist. He failed the 11-plus and when he left secondary school at 15, the headmaster told his mother that he would never amount to much. He became a steward on ocean liners sailing out of Liverpool. Mrs Blair’s father was a well-known Liverpudlian actor called Tony Booth, a boozer who abandoned his family before Mrs Blair was ten years old. http://louisijisheehan.blogspot.com



She had a strict Catholic education. The nuns identified her as an ill-disciplined child who would never make prefect, never mind head girl, but she was clever and independent-minded. She chose to study law at the London School of Economics, where she was able to shower every day in her student residence instead of sharing a bath with the rest of her family once a week.

Lord Levy and Mr Prescott freely admit to having a chip on their shoulders, and a streak of vanity which drove them on. Mr Prescott became an MP sponsored by the National Union of Seamen, rising to become Labour’s leading class warrior, and deputy prime minister. Lord Levy, who started a record label (his star performer was Alvin Stardust) and became rich when he sold it, was a celebrated fund-raiser for Jewish charities. He performed the same role for Tony Blair so successfully that he became known as Lord Cashpoint.

Mrs Blair became a QC, and the story of her legal career is rather more interesting than her score-settling account of life as the prime minister’s wife. She was a junior in the chambers of the future Lord Chancellor, Derry Irvine, and watched him in combat with Tom Bingham, later Lord Chief Justice. “Derry was like an attacking rhinoceros. Tom Bingham on the other hand was like a snake, smooth, charming, almost hypnotic, exposing the weakness in the other side’s argument without ever raising his voice. Bingham subsequently became my role model. As a woman I could never have been as aggressive an advocate as Derry.”

Where did it all go wrong? Mr Prescott felt deeply that he was unappreciated: “I got branded as an uneducated yob. It was an image I suppose never left me. I began to hate the press.” He developed bulimia, caused in part, he says, by stress. An affair with his diary secretary tore at the last vestiges of his authority. His book, which is a lazy, once-over-lightly non-apology of a life, does not restore it.

Lord Levy comes across as a more sympathetic character. He has written the case for his defence in the recent cash-for-honours scandal that involved even Mr Blair. As a vain man, he was particularly proud of his role as Mr Blair’s Middle East envoy, but he acknowledges that he suffered from hubris. “I sometimes revelled in the public attention. In politics I had sometimes been blinded by the light.”

Mrs Blair’s problem is that she could never keep quiet: “I have never been taught the meaning of the phrase ‘discretion is the better part of valour’.” She is a doughty hater, with Gordon Brown as her principal antagonist, and Alistair Campbell and the Princesses Margaret and Anne not far behind. Her loyalty to Mr Blair is absolute: “There were times when I faltered...But I knew him and knew he would never do the wrong thing.” Her book is easily outselling the others, and deserves to, but each leads irresistibly to the same conclusion: there are very few happy endings in British politics.






Tens of thousands of teachers formed picket lines outside nearly 900 schools here Friday morning to protest cuts to education financing proposed by Gov. Arnold Schwarzenegger to help close California’s projected $17 billion budget gap.

If passed, the cuts would reduce financing for Los Angeles schools by $340 million next year, said A. J. Duffy, president of United Teachers of Los Angeles, the local teachers union.

Mr. Duffy said the union, which represents 48,000 teachers, had announced plans for the hourlong protest more a month ago, allowing principals and teachers in the Los Angeles Unified School District, the nation’s second-largest K-12 public school system, to work together to plan supervision of almost 700,000 students between 7:30 and 8:30 a.m. Substitute teachers and administrators from neighboring districts were brought in to sit with students in auditoriums, gymnasiums and on playgrounds, he said.

When the protest ended at 8:30 a.m., teachers reported to their classrooms for their regular duties. http://ljsheehan.blogspot.com


School district officials said they opposed the budget cuts, but denounced the protest as a disruption of the school day. The district failed to win a court injunction in early May to prevent teachers from leaving their classes to take part in the protest.

On Thursday night, Superintendent David Brewer sent an automated call to parents, notifying them of the protest and calling it “the wrong message” to send to legislators and to the community.

At 7:30 Friday morning, teachers wearing red T-shirts and carrying signs with slogans like “Honk for No Budget Cuts” were joined by some parents on sidewalks outside their schools. Many smiled and waved at morning commuters, some of whom sounded their horns.



Retirements are increasing from a baby boomer generation of teachers and others in the state's public education system, taking with them years of invaluable classroom experience.

As many as 12,000 retirements are expected this year alone by the Pennsylvania Public School Employees Retirement System, while the Pennsylvania State Education Association says 30 percent of the state's teachers -- there were more than 123,000 in the profession as of 2005-06 -- are within five years of their normal retirement age.

Officials of several midstate school districts say colleges are producing enough capa ble graduates and that many are more sophis ticated in technology and other modern edu cation than prior generations.

But short ages exist in key subjects such as math, language, physics and chemistry -- skills needed by employers and ones that likely are going to become even more crucial in the future. There also continues to be a lack of minorities going into teaching, an issue that urban districts in particular are finding challenging.

The Harrisburg School District, for example, had a 94.7 percent minority student population last year, but only 23 percent of its teachers represented minorities.

There is much to be said for teacher training and majoring in education in terms of one's ability to be effective in the classroom. But the retirement wave on top of shortages of teachers in certain subject areas and the dearth of minorities reinforce the need to revisit federal and state certification requirements that have been tightened in recent years under the No Child Left Behind Act and Pennsylvania's Teachers for the 21st Century Initiative.

Although perhaps well-intentioned, they have presented huge obstacles for nonteaching professionals looking to make a career change and who have much to offer students. Prior to No Child Left Behind, a school district would take a person with an MBA and a background conducive to teaching math, economics or business, put him or her in the classroom immediately and have the individual work toward completing a list of courses needed for teaching certification.

Now, the certification must come first, meaning the applicant would likely have to bear the financial hardship of quitting his or her job while taking classes.

They do have the option of taking and passing the national teachers exam, something Mark Holman, director of human resources for the Harrisburg School District, has compared to "trying to pass the bar exam before going to law school."

Meanwhile, since the 2003-04 school year, the initiative launched under the Ridge administration require teachers graduating college to have a 3.0 grade point average. But some students for reasons of maturity, homesickness or personal hardship struggle with their studies their freshmen and sophomore years, then turn it around and become A and B students their remaining years. In those cases, the GPA is misleading.

The state should reconsider these GPA requirements and Congress should revisit the certification issue while debating reauthorization of the No Child Left Behind Act. Not only have the federal and state governments usurped local discretion in the hiring process, they are keeping some potentially good teachers out of the classroom.








Hose or no hose? That's the working woman's dilemma around this time of year. The weather grows warmer, and the debate heats up: Are bare legs proper?


In today's casual workplaces, many women have peeled off the panty hose, and it is now common to see bare legs even on conservative Wall Street and at business events. Yet the transition has highlighted a generational divide. For women who entered the work force before the 1990s, hose were considered as necessary as underwear. But many twentysomethings have never worn panty hose at all. http://louisajasheehan.blogspot.com


The fashion shift has left some baby boomer managers feeling that their hose make them look frumpy. Kathy Garland, the 54-year-old chairwoman of the Northern Dallas area for the National Association of Women Business Owners, says she finally threw out a bag full of hose last week. An executive coach herself, she noticed a few years ago that she was the only woman wearing hose at a formal business fund-raiser. "Younger women don't even think about panty hose," she says.

There are certainly weightier issues to ponder these days, what with a presidential election and a war going on. But to managers in offices encompassing several generations, panty-hose policies are an opportunity to set fair rules.
Attached to this memo is an update of our dress code that I have approved and is effective immediately, subject to final approval of our Board (as are all official policies).
This change makes the wearing of hose by females optional with both business and business casual. http://Louis-J-sheehan.info


Our standards are based on what is generally and widely accepted as the professional dress standard consistent with conservative professional appearance. The reason for this change is a result of legitimate questions by prospective staff members about this standard. Kristen contacted nearly two-dozen local financial institutions about their standard in this area. She also contacted the Wichita Eagle, and I consulted with the professional business-wear reporter for the Wall Street Journal. The vast majority responded that hose was an option with dresses, skirts and slacks in the professional world. Since this is the marketplace standard, we are adopting it.

Please be aware that these are minimum standards. What we truly want is for our members to see us in the most professional light that is reasonable. We encourage you to look your best with these minimum standards as your guide.
Personally, I believe hose enhance a woman's professional appearance and would be the preferred choice for upwardly mobile women both here and in other professional organizations. Please feel free to make the choice you believe presents you in the most professional way to our members-our ultimate judge.

This is the issue that lately has occupied the mind of Jim Holt, president of Mid American Credit Union, a small financial institution in Wichita, Kan. Mr. Holt is 58 and a three-decade member of the U.S. Army Reserves. He joined Mid American, which has 50 employees, four years ago, inheriting a dress code that prohibited, for women, such things as boots and mules, or backless shoes. The company required "hose" at all times -- even under pants.

When Mr. Holt attended a dress-for-success seminar that year, he got advice that caused him to loosen the reins on women's boots and mules. But not bare legs. The rule, "nylon hose and dress shoes are to be worn at all times," applied even to business-casual contexts. "We're not New York or San Francisco," Mr. Holt says, wearing ironed khaki slacks, an ironed golf shirt, and crisply creased socks. "We're the Midwest." http://Louis-J-sheehan.info



If there is a male equivalent of panty hose -- forcing wearers to balance comfort and formality -- it is probably the tie. Ties aren't required at Mid American. "The revolution has already taken place in the tie area," says Mr. Holt. He wears ties only on Mondays for his weekly Rotary Club luncheons.

As for fairness, it's hard to say whether ties or panty hose are more uncomfortable. One male reader of this newspaper, after making a bet with a female co-worker, attempted to discover the answer by secretly wearing panty hose under his business suit for several weeks. He claims ties are worse.

About a year and a half ago, Mr. Holt hired Kristen Spear as executive director of administration and human resources. Ms. Spear is 28. Like Ms. Garland in Texas, Ms. Spear found that wearing hose to professional events sometimes made her stand out awkwardly. Yet it was her job to counsel wayward employees on Mid American's dress code, which she did dutifully if not enthusiastically.

One bare-legged 23-year-old clerk in indirect loans -- where she dealt with customers by phone -- confessed she had never owned a pair of hose. Hose are "so foreign right now to Gen Y or Gen X," Ms. Spear says.

Ms. Spear encouraged Mr. Holt to reconsider his stand on hose. "According to her local research, hose are optional," Mr. Holt said in a recent email to me.

He relented just last week. "I didn't want to be so old-fashioned that people would be like, 'Do you require corsets, too?'" he said.

Mid American's newly loosened dress code, allowing bare legs, will be announced to employees in coming weeks in a series of meetings. Women at the credit union would be well-advised to listen closely. Mr. Holt says that when evaluating employees' performance in dress, as well as workmanship, he'll make a distinction between "who is meeting the minimum standards and who is exceeding them." In other words, hose will be optional but advised. http://Louis-J-sheehan.info



I suspect it is only a matter of time until Ms. Spear's point of view wins out entirely.

For the time being, Ms. Spear says she'll wear hose to board meetings "or if there is reason to exude the highest professional appearance. I will not wear them if I will be in the office all day, because I believe one can be professional-looking without wearing hose."





How to Date a Playboy Bunny

Step1
Be attractive. While you do not have to be the best looking person in the world, you do have be attractive or at least have an attractive personality trait. No Bunny wants to date a loser. You may need to have plastic surgery done to improve your appearance.
Step2
Find a retired Playboy Bunny. You need to find someone who worked as Bunny. You can hire a private detective, or you can attend one of the advertised events that the Bunnies hold. These events are generally charity fund-raisers. You could also plan to attend a Playboy Club reunion. The reunion is for former Playboy Club employees, but you can generally find the location for the event.
Step3
Visit the Playboy Mansion. While most of the women at the mansion are Playmates and might make you forget your quest to date a Bunny, a few Bunnies have been known to visit. You can also meet people who know Bunnies and can put you in contact with them.
Step4
Be open sexually. The premise of Hugh Hefner's "Playboy" is open sexuality. If you are not comfortable with your sexuality, you are in the wrong arena for dating. Some Bunnies prefer women, others look both ways and some just want to have an open relationship.
Step5
Watch for international Bunnies. Hugh Hefner currently has plans to revive the Bunnies at a new Playboy Mansion planned to open in China.









Dr. Jacob Robbins, whose studies of the thyroid gland at the National Institutes of Health helped explain how it helps govern metabolism and how thyroid cancers caused by radiation may be treated or possibly prevented, died on May 12 in Bethesda, Md. He was 85.

The cause was heart failure, his family said.

With another endocrinologist at the health institutes, Joseph E. Rall, Dr. Robbins embarked on a study of thyroxine, an important hormone produced by the thyroid that helps regulate metabolism. In the 1950s, the two researchers theorized that levels of thyroxine might vary in the bloodstream, but that the level of thyroxine actually in use would often be markedly lower. They found that thyroxine had to be “free,” or not bound to globulin and other plasma proteins, to be effective, whatever the overall thyroxine level in the bloodstream.

The findings of Dr. Robbins and Dr. Rall yielded insights about what are “normal and pathologic states in the thyroid, and how to distinguish between them,” said Dr. Phillip Gorden, an endocrinologist who directed the National Institute of Diabetes and Digestive and Kidney Diseases at the N.I.H. from 1986 to 1999. The observations have also aided physicians and pharmaceutical companies in developing targeted dosages of thyroxine, which in some pregnant women helps prevent or treat hypothyroidism, a hormone deficiency that can cause lasting developmental problems in infants.

In further fruitful collaborations with Dr. Rall and others, Dr. Robbins studied incidences of thyroid cancer in patients exposed to radioactive fallout from nuclear testing. Earlier, in the 1950s, he had examined the therapeutic properties of radioactive iodine when used to pinpoint and treat cancer in the thyroid. In the decades that followed, Dr. Robbins became an authority on the harmful effects of radioactive iodine released spontaneously into the atmosphere.

At the health institutes, Dr. Robbins helped direct long-term studies of the survivors of nuclear tests and accidents, and he followed the health effects of iodine fallout after the Chernobyl reactor meltdown in Ukraine in 1986 and after American weapons testing in the Marshall Islands from the 1940s to the 1980s. He joined a vocal group of scientists who called for wider availability of a drug that can help prevent thyroid cancers from showing up after intense exposures to radiation. That drug, potassium iodide, is taken orally and floods the thyroid with iodine to block the absorption of radioactive iodine.

Dr. Robbins argued that people living near commercial nuclear reactors, particularly children, should have immediate access to potassium iodide. He urged the federal government to stockpile the drug and widen its potential distribution. http://louisdjdsheehan.blogspot.com




In 2001, he told The New York Times, “To me, the smart thing to do would be to have it in homes, in blister packs with adhesive backs.”

Jacob Robbins was born in Yonkers. He studied chemistry at Cornell before earning a medical degree there in 1947.

Dr. Robbins joined the health institutes as an investigator in 1954. He was chief of the clinical endocrinology branch at the National Institute of Diabetes and Digestive and Kidney Diseases from 1963 to 1991. The health institutes named him a scientist emeritus in 1995.

Dr. Robbins was a president of the American Thyroid Association. From 1968 to 1972, he was editor in chief of the journal Endocrinology.

Dr. Robbins is survived by his wife, the former Jean Adams. The couple lived in Bethesda. He is also survived by a son, Mark, of Seattle; two daughters, Alice of Amherst, Mass., and Susan of Shelburne Falls, Mass.; a brother, Lionel, of Bloomfield Hills, Mich.; a sister, Evelyn Savitzky of Pittsboro, N.C.; and four grandchildren.



how the business works and how the operators of the state’s estimated 500 dispensaries deal with the high risks and high costs of working in a legal gray area (cnbc.com).

Medical marijuana is legal in California, but federal law still bans sales. Amid the uncertainty that this creates — including the occasional raid by federal agents — a full-fledged industry has blossomed, taking in about $2 billion a year and generating $100 million in state sales taxes, CNBC reported.

Setting up a clinic “can cost as much as a hundred grand,” Ms. Wells reports. The equipment, the cuttings from which plants are grown and office space all tend to be expensive. And from there, the costs only grow, mostly in the form of legal fees. Many clinics keep lawyers on retainer.

Nonetheless, “this is the business model of the future,” says JoAnna La Force of Farmacy, an herbal remedy shop in Southern California. Ms. LaForce says her business is close to breaking even (medicalmarijuanafarmacy.com).

A slew of ancillary businesses has grown up around medical marijuana. Bill Britt, identified on the Web site as a patient, has found a new career as an expert witness in cases brought against dispensaries and patients, earning $250 to $350 a case.

He gained his expert knowledge by attending Oaksterdam University, a trade school in Oakland, Calif. At Oaksterdam (oaksterdamuniversity.com), students learn everything from “The Politics of Cannabis” to botany to business operations.

Getting into the quasi-legitimate marijuana business is a challenge, says Jeff Jones, chancellor of Oaksterdam’s Los Angeles campus. But, he adds, “The investment is well worth it, except for the federal risk.”

As air travel grows increasingly nightmarish even as it gets more expensive, Patrick Smith, writer of Salon’s Ask the Pilot column, has been singing the praises of Southwest Airlines, the (relatively) cut-rate, bare-bones carrier.

Southwest recently took first place in a survey of airline satisfaction conducted by the University of Michigan.

Mr. Smith’s initial explanation was this: “People don’t expect much. Southwest Airlines is nothing if not unpretentious” and has “mastered the art of get-what-you-pay-for satisfaction.”

His readers, though, thought otherwise. Many wrote to say that, though Southwest dispenses with a lot of perks, it offers a basic level of customer service that bigger airlines often do not.

Mr. Smith acknowledged that Southwest’s comparatively small size gave it an advantage in maintaining a consistent level of service. Nevertheless, it is “the last of a nearly vanished breed: an airline with a true personality, that large numbers of fliers have unwavering fondness for.”

As a test of airport security, a customs officer planted marijuana in the side pocket of a random suitcase at Narita International Airport in Tokyo, the BBC reports (news.bbc.co.uk).

The test failed when the sniffer dogs were unable to detect the pot. But the officer could not remember which bag he had used.

Using an actual passenger’s suitcase is against regulations, and the airport’s customs service has apologized.

Meanwhile, the marijuana is still out there. “Anyone finding the package has been asked to contact customs officials,” according to the BBC. So far, nobody has spoken up. http://louiskjksheehan.blogspot.com

For years, scientists have had a straightforward idea for taming global warming. They want to take the carbon dioxide that spews from coal-burning power plants and pump it back into the ground.

President Bush is for it, and indeed has spent years talking up the virtues of “clean coal.” All three candidates to succeed him favor the approach. So do many other members of Congress. Coal companies are for it. Many environmentalists favor it. Utility executives are practically begging for the technology.

But it has become clear in recent months that the nation’s effort to develop the technique is lagging badly.

In January, the government canceled its support for what was supposed to be a showcase project, a plant at a carefully chosen site in Illinois where there was coal, access to the power grid, and soil underfoot that backers said could hold the carbon dioxide for eons.

Perhaps worse, in the last few months, utility projects in Florida, West Virginia, Ohio, Minnesota and Washington State that would have made it easier to capture carbon dioxide have all been canceled or thrown into regulatory limbo.

Coal is abundant and cheap, assuring that it will continue to be used. But the failure to start building, testing, tweaking and perfecting carbon capture and storage means that developing the technology may come too late to make coal compatible with limiting global warming.

“It’s a total mess,” said Daniel M. Kammen, director of the Renewable and Appropriate Energy Laboratory at the University of California, Berkeley.

“Coal’s had a tough year,” said John Lavelle, head of a business at General Electric that makes equipment for processing coal into a form from which carbon can be captured. Many of these projects were derailed by the short-term pressure of rising construction costs. But scientists say the result, unless the situation can be turned around, will be a long-term disaster.

Plans to combat global warming generally assume that continued use of coal for power plants is unavoidable for at least several decades. Therefore, starting as early as 2020, forecasters assume that carbon dioxide emitted by new power plants will have to be captured and stored underground, to cut down on the amount of global-warming gases in the atmosphere.

Yet, simple as the idea may sound, considerable research is still needed to be certain the technique would be safe, effective and affordable.

Scientists need to figure out which kinds of rock and soil formations are best at holding carbon dioxide. They need to be sure the gas will not bubble back to the surface. They need to find optimal designs for new power plants so as to cut costs. And some complex legal questions need to be resolved, such as who would be liable if such a project polluted the groundwater or caused other damage far from the power plant.

Major corporations sense the possibility of a profitable new business, and G.E. signed a partnership on Wednesday with Schlumberger, the oil field services company, to advance the technology of carbon capture and sequestration.

But only a handful of small projects survive, and the recent cancellations mean that most of this work has come to a halt, raising doubts that the technique can be ready any time in the next few decades. And without it, “we’re not going to have much of a chance for stabilizing the climate,” said John Thompson, who oversees work on the issue for the Clean Air Task Force, an environmental group.


The fear is that utilities, lacking proven chemical techniques for capturing carbon dioxide and proven methods for storing it underground by the billions of tons per year, will build the next generation of coal plants using existing technology. That would ensure that vast amounts of global warming gases would be pumped into the atmosphere for decades.

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