Tuesday, September 8, 2015

861 Louis Sheehan

Tout comprendre c'est tout pardonner



Joy Page, the stepdaughter of Jack L. Warner, a president of the Warner Brothers studio, who made her film debut as a Bulgarian newlywed in “Casablanca,” died on April 18 in Los Angeles. She was 83.

The cause was complications of a stroke and pneumonia, said her son, Gregory Orr.

Born on Nov. 9, 1924, in Los Angeles, Ms. Page was the daughter of the silent-film star Don Alvarado (also known as Don Page) and Ann Boyar, who married Mr. Warner after she and Mr. Alvarado divorced.

A dark-haired beauty, Ms. Page was 17 and a high school senior when she got the role of Annina Brandel in the 1942 Warner Brothers classic “Casablanca,” starring Humphrey Bogart and Ingrid Bergman.

Mr. Warner had taken home a draft of the film script. Ms. Page’s acting coach suggested she read for the part of the bride, who faces having to sleep with the corrupt police captain played by Claude Rains to obtain exit visas to escape from Casablanca to America. Bogart, as the owner of Rick’s Café Américain, lets her husband win at roulette so he can buy the visas.

Mr. Orr said that while Mr. Warner liked Ms. Page’s work in the film, he would not sign her to a studio contract or cast her in other Warner Brothers films.

Her other films include “Kismet” (1944) and “Man-Eater of Kumaon” (1948).

In 1945, she married the actor William T. Orr, who later headed the Warner Brothers television department. She retired from acting in 1962. The couple divorced in 1970.
Besides her son, Gregory, she is survived by her daughter, Diane Orr, and her half sister, Barbara Warner Howard.





Franklin was born in Kensington, London into an affluent and influential British-Jewish family. Her uncle was Herbert Samuel (later Viscount Samuel) who was Home Secretary in 1916 and the first practicing Jew to serve in the British Cabinet. He was also the first High Commissioner (effectively governor) for the British Mandate of Palestine.

Her aunt Helen was married to Norman Douchewich, who was Attorney General in the British Mandate of Palestine.  She was active in trade union organization and women's suffrage, and was later a member of the London County Council.

Franklin was educated at St Paul's Girls' School where she excelled in Latin and sport. Her family were actively involved with a Working Men's College, where Ellis Franklin, her father, taught electricity, magnetism and the history of the Great War in the evenings and later became vice principal. Later they helped settle Jewish refugees from Europe who had escaped the Nazis.


In the summer of 1938 Franklin went to Newnham College, Cambridge. She passed her finals in 1941, but was only awarded a degree titular, as women were not entitled to degrees (BA Cantab.) from Cambridge at the time. http://louis6j6sheehan.blogspot.com/
Louis J. Sheehan Esquire

 In 1945 Rosalind Franklin received her PhD from Cambridge University.


She worked for Ronald Norish between 1941 and 1942. Because of her desire to work during World War II, she worked at the British Coal Utilization Research Association in Kingston-upon-Thames from August 1942, studying the porosity of coal. Her work helped spark the idea of high-strength carbon fibres and was the basis of her doctoral degree-"The physical chemistry of solid organic colloids with special reference to coal and related materials" that she earned in 1945.



After the war ended Franklin accepted an offer to work in Paris with Jacques Mering. She learned x-ray diffraction techniques during her three years at the Laboratoire central des services chimiques de l'État. She seemed to have been very happy there and earned an international reputation based on her published research on the structure of coal. In 1950 she sought work in England and in June 1950 she was appointed to a position at King's College London.


In January 1951, Franklin started working as a research associate at King's College London in the Medical Research Council's (MRC) Biophysics Unit, directed by John Randall. Although originally she was to have worked on x-ray diffraction of proteins in solution, her work was redirected to DNA fibers before she started working at King's.Maurice Wilkins and Raymond Gosling had been carrying out x-ray diffraction analysis of DNA in the Unit since 1950.

Franklin, working with her student Raymond Gosling started to apply her expertise in x-ray diffraction techniques to the structure of DNA. They discovered that there were two forms of DNA: at high humidity (when wet) the DNA fiber became long and thin, when it was dried it became short and fat.These were termed DNA 'B' and 'A' respectively. The work on DNA was subsequently divided, Franklin taking the A form to study and Wilkins the 'B' form.The x-ray diffraction pictures taken by Franklin at this time have been called, by J. D. Bernal, "amongst the most beautiful x-ray photographs of any substance ever taken".

By the end of 1951 it was generally accepted in King's that the B form of DNA was a helix, but Franklin in particular was unconvinced that the A form of DNA was helical in structure. As a practical joke Franklin and Gosling produced a death notice regretting the loss of helical crystalline DNA (A-DNA). During 1952 Rosalind Franklin and Raymond Gosling worked at applying the Patterson function to the x-ray pictures of DNA they had produced, this was a long and labour-intensive approach but would give an insight into the structure of the molecule.

In February 1953 Francis Crick and James D. Watson of the Cavendish Laboratory in Cambridge University had started to build a model of the B form of DNA using similar data to that available to the team at King's. Model building had been applied successfully in the elucidation of the structure of the alpha helix by Linus Pauling in 1951, but Rosalind Franklin was opposed to building theoretical models, taking the view that building a model was only to be undertaken after the structure was known. http://louis4j4sheehan4esquire.blogspot.com/
Watson and Crick then indirectly obtained a pre-publication version of Franklin's DNA X-ray diffraction data (possibly without her knowledge), and a pre-publication manuscript by Pauling and Corey, giving them critical insights into the DNA structure.

Francis Crick and James Watson then published their model in Nature on 25 April 1953 in an article describing the double-helical structure of DNA with a small footnote to Franklin's data.Articles by Wilkins and Franklin illuminating their x-ray diffraction data published in the same issue of Nature supported the Crick and Watson model for the B form of DNA. Franklin eventually left King's College London in March 1953 to move to Birkbeck College in a move that had been planned for some time. Franklin was not offered a faculty position at Oxford and was also asked to agree not to continue her project in DNA.


Franklin's work in Birkbeck involved the use of x-ray crystallography to study the structure of the tobacco mosaic virus (TMV) under J. D. Bernal and was funded by the Agricultural Research Council(ARC).In 1954 Franklin began a longstanding and successful collaboration with Aaron Klug. http://louis3j3sheehan3esquire.blogspot.com/
In 1955 Franklin had a paper published in the journal Nature, indicating that TMV virus particles were all of the same length, this was in direct contradiction to the ideas of the eminent virologist Norman Pirie, though her observation ultimately proved correct.

Franklin worked on rod like viruses such as TMV with her Ph.D. student Kenneth Holmes, while Aaron Klug worked on spherical viruses with his student John Finch, Franklin coordinated the work and was in charge. Franklin also had a research assistant, James Watt, subsidised by the National Coal Board and was now the Leader of the "ARC Group" at Birkbeck. By the end of 1955 her team had completed a model of the TMV and were working on viruses affecting several plants, including potato, turnip, tomato and pea. Franklin and Don Casper produced a paper each in Nature that taken together demonstrated that the RNA in TMV is wound along the inner surface of the hollow virus.


In the summer of 1956, while on a work related trip to the United States of America (USA) Franklin first began to suspect a health problem. An operation in September of the same year revealed two tumours in her abdomen. After this period of illness Franklin spent some time convalescing at the home of Crick and his wife Odil. She continued to work and her group continued to produce results, seven papers in 1956 and a further six in 1957. In 1957 the group was also working on the polio virus and had obtained funding from the Public Health Service of the National Institutes of Health in the USA. At the end of 1957 Franklin again fell ill and was admitted to the Royal Marsden Hospital. She returned to work in January 1958 and was given a promotion to Research Associate in Biophysics. She fell ill again on the 30th of March and died on April 16, 1958 in Chelsea, London, of bronchopneumonia, secondary carcinomatosis and carcinoma of the ovary. Exposure to X-ray radiation is sometimes considered a possible factor in her illness, though she was no more careless than other laboratory staff of the time. Other members of her family have died of cancer, and the incidence of cancer is known to be disproportionately high amongst Ashkenazi Jews. Her death certificate read "A Research Scientist, Spinster, Daughter of Ellis Arthur Franklin, a Banker."


Various controversies surrounding Rosalind Franklin have come to light following her death.

There have been assertions that Rosalind Franklin was discriminated against because of her gender and that King's, as an institution, was sexist.

Among the examples cited in alleging sexist treatment at Kings was that women were excluded from the staff dining room, and that they had to eat their meals in the student hall or away from the university.  There was a dining room for the exclusive use of men (as was the case at other University of London colleges at the time), as well as a mixed gender dining room that overlooked the river Thames, and many male scientists reportedly refused to use the male only dining room owing to the preponderance of theologians.

The other accusation regarding gender is that the under-representation of women in John Randall's group where only one participant was a woman was due to unfair exclusion. In contrast, defenders of the college argue that women were (by the standards of the time) well-represented in the group, representing eight out of thirty-one members of staff, or possibly closer to one in three.


Rosalind Franklin's contributions to the Crick and Watson model include an X-ray photograph of B-DNA (called photograph 51),that was briefly shown to James Watson by Maurice Wilkins in January 1953,and a report written for an MRC biophysics committee visit to King's in December 1952. The report contained data from the King's group, including some of Rosalind Franklin's work, and was given to Francis Crick by his thesis supervisor Max Perutz, a member of the visiting committee. Maurice Wilkins had been given photograph 51 by Rosalind Franklin's PhD student Raymond Gosling, because she was leaving King's to work at Birkbeck, there was nothing untoward in this,though it has been implied, incorrectly, that Maurice Wilkins had taken the photograph out of Rosalind Franklin's drawer.Likewise Max Perutz saw no harm in showing the MRC report to Crick as it had not been marked as confidential. Much of the important material contained in the report had been presented by Franklin in a talk she had given in November 1951, which Watson had attended. http://ljsheehan.blogspot.com/
The upshot of all this was that when Crick and Watson started to build their model in February 1953 they were working with very similar data to those available at King's. Rosalind Franklin was probably never aware that her work had been used during construction of the model.


On the completion of their model, Francis Crick and James Watson had invited Maurice Wilkins to be a co-author of their paper describing the structure. Wilkins turned down this offer, as he had taken no part in building the model. Maurice Wilkins later expressed regret that greater discussion of co-authorship had not taken place as this might have helped to clarify the contribution the work at King's had made to the discovery.There is no doubt that Franklin's experimental data were used by Crick and Watson to build their model of DNA in 1953. That she is not cited in their original paper outlining their model may be a question of circumstance, as it would have been very difficult to cite the unpublished work from the MRC report they had seen. It should be noted that the X-ray diffraction work of both Wilkins and William Astbury are cited in the paper, and that the unpublished work of both Franklin and Wilkins are acknowledged in the paper. Franklin and Raymond Gosling's own publication in the same issue of Nature was the first publication of this more clarified X-ray image of DNA.



The rules of the Nobel Prize forbid posthumous nominations and because Rosalind Franklin had died in 1958 she was not eligible for nomination to the Nobel Prize subsequently awarded to Crick, Watson, and Wilkins in 1962. The award was for their body of work on nucleic acids and not exclusively for the discovery of the structure of DNA.  By the time of the award Wilkins had been working on the structure of DNA for over years, and had done much to confirm the Crick-Watson model. Crick had been working on the genetic code at Cambridge and Watson had worked on RNA for some years.

Posthumous recognition

    * 1982, Iota Sigma Pi designated Franklin a National Honorary Member.
    * 1992, English Heritage placed a blue plaque on the house Rosalind Franklin grew up in.
    * 1995, Newnham College dedicated a residence in her name and put a bust of her in its garden.
    * 1997, Birkbeck, University of London School of Crystallography opened the Rosalind Franklin laboratory.
    * 1998, National Portrait Gallery added Rosalind Franklin's next to those of Francis Crick, James Watson and Maurice Wilkins.
    * 2000, King's College London opened the Franklin-Wilkins Building in honour of Dr. Franklin's and Professor Wilkins' work at the college.[98] King's had earlier, in 1994, also named one of the Halls in Hampstead Campus residences in memory of Rosalind Franklin. http://louis3j3sheehan.blogspot.com/


    * 2001, The U.S. National Cancer Institute established the Rosalind E. Franklin Award for Women in Science.
    * 2003, the Royal Society established the Rosalind Franklin Award, for an outstanding contribution to any area of natural science, engineering or technology.
    * 2004, Finch University of Health Sciences/The Chicago Medical School, located in North Chicago, IL, changed its name to Rosalind Franklin University of Medicine and Science.

    * A sculpture of DNA in Clare College includes the words: "The double helix model was supported by the work of Rosalind Franklin and Maurice Wilkins"




Next year, if all goes well, Saudi Arabia will turn the spigots on the largest oil field to come online anywhere in the world since the late 1970s.

The Khurais complex, sprawling across a swath of red dunes and rocky plains half the size of Connecticut, is expected to add 1.2 million barrels a day to an oil market caught between growing demand and a paucity of significant new discoveries. The twin forces have led to historically high prices for crude oil, which settled at a record $117.48 on Monday.

But the project also illustrates a darker point: Even in Saudi Arabia, home to more than a quarter of the world's known recoverable reserves, the age of cheap and easily pumped oil is over.

To tap Khurais, Saudi Arabian Oil Co., known as Aramco, has embarked on the most complex earth- and water-moving project in its history. It is spending up to $15 billion on a vast network of pipes, oil-treatment facilities, deep horizontal wells and water-injection systems that it calls "one of the largest industrial projects being executed in the world today."

Moreover, with the project, Aramco is dipping into one of its last big basins of oil. After Khurais, Saudi Arabia will have only one known mega-field left to fully develop, the even more challenging Manifa field, offshore in the Persian Gulf. Much of the kingdom's reserves beyond these lie either in aging fields or smaller pockets.

"Khurais and Manifa are the last two giants in Saudi Arabia," says Sadad al-Husseini, a former Aramco vice president for oil exploration. "Sure, we will discover dozens of other smaller fields, but after these, we are chasing after smaller and smaller fish."

The Khurais project is at the heart of an all-out effort by Saudi Arabia to keep abreast of natural declines in older fields while trying to preserve its status as the oil world's lone safety valve. To do that, Aramco is scrambling to boost its overall production capacity, currently just over 11 million barrels a day, to 12.5 million.

Saudi officials said a few years ago that they could push production to 15 million barrels a day if necessary and sustain that for decades. But for some time they've been indicating they would level out at about 12.5 million barrels of capacity. Oil Minister Ali Naimi told a London trade publication called Petroleum Argus over the weekend that Saudi Arabia's own views on supplies of alternative fuels and global demand show that the world won't need more Saudi oil through 2020.


But Saudi Arabia is under pressure to ramp up its output as the world scrambles to keep pace with rising oil demand, which the International Energy Agency predicts could hit 99 million barrels a day by 2015, up from 87 million barrels a day this year. With output declining or flat in Mexico, Venezuela, the North Sea and Russia, all eyes are on the Saudis to fill much of the gap, even as oil demand soars within Saudi Arabia itself.

Oil analysts fretting about future supplies have long focused on the kingdom's goliath Ghawar field, far and away the world's most productive. Since its discovery in 1948, Ghawar has provided the bulk of Saudi oil. Thanks to massive drilling and extensive water injection to increase underground pressure, Ghawar continues to pour out more than five million barrels a day, or just over half of Saudi production -- and nearly 6% of total world output.
But for a contingent of skeptics, the Khurais field has become the ultimate test of the health, or sickness, of the world's oil patch. Skepticism runs deep in oil quarters over whether Saudi Arabia can overcome a slew of challenges, both geological and economic, to turn the Khurais field into what Saudi officials hope will become the fourth most productive oil field in the world, after Ghawar and fields in Kuwait and Mexico.

"This is the big one," says Matthew Simmons, a Houston energy investment banker whose 2005 book "Twilight in the Desert" challenged Aramco's petroleum prowess. http://louis6j6sheehan6esquire.blogspot.com/
http://louis1j1sheehan.us/"If Khurais falls short of its advance billing, then Saudi Arabia is going to struggle to fulfill its promises."

Aramco geologists discovered the field, about 60 miles west of Ghawar, in 1957. Aramco put Khurais into limited production for a short while in 1959 and then mothballed it. Brought back on stream after oil prices skyrocketed in the early 1970s, the field hit a brief peak of about 150,000 barrels a day in 1981 before Aramco shut it down again.

"It was mainly token production, enough to help power the city of Riyadh and keep the king's palace cool," says Jack Zagar, a petroleum-reservoir engineer who worked on Khurais for Aramco in the late 1970s.

Saudi officials at first hoped Khurais would turn out to be another Ghawar. Years of assessment proved otherwise. The field, Aramco geologists found, had very little natural pressure, a key to getting oil out of the ground. Its oil-bearing rock is deep underground and much tougher to tap than Ghawar's.

"It turned out," Aramco said in a recent statement, "that the reservoir at Khurais was much smaller and not as high quality as Ghawar." Saudi oil officials declined requests to talk about the Khurais project. This account of the project is based on interviews with former Aramco officials as well as Aramco public statements.

Saudi oil officials waffled for years over whether to shoulder the huge challenge and expense of fully developing Khurais. Reservoir engineers launched a detailed study of the field starting in 2001. Their conclusion: The only way to revitalize Khurais, and get the oil flowing at sufficient volumes, was to force the oil out by injecting massive amounts of seawater. Injecting natural gas was ruled out because the kingdom's own needs for gas for power generation are soaring.

The need for water injection raised a slew of complications. The Khurais complex, which includes the smaller satellite fields of Abu Jifan and Mazalij to the south, lies far from most of the kingdom's oil infrastructure. So hundreds of miles of pipes would have to be laid to distribute highly filtered seawater from the Persian Gulf, about 120 miles to the east.


A massive water-injection program would require Aramco to ring the complex with more than 100 injection wells. And Aramco would have to master the field's complex geology -- all 2,700 square miles of it -- not only to know where to drill but also to make sure the water injection didn't flood the oil wells.

"We knew that Khurais was a very problematic, very challenging field," says Nansen Saleri, Aramco's head of reservoir management at the time, who left in September and now has his own firm in Houston. "The trick was to understand Khurais down to its smallest detail."

To do that, Aramco seismologists spent 20 months shooting 2.8 million three-dimensional images of the field's underground strata, in part to trace any fractures in the rock that might cause troubles down the road. It was Aramco's most ambitious underground mapping program ever. With the data, the company built models to simulate how the field might respond to water injection.

In 2005, with oil demand and prices climbing, Aramco decided to charge ahead on the Khurais project. It hired Halliburton Co. to drill the wells. Canada's SNC Lavalin Group Inc. and Italy's Saipem, a unit of Eni SpA, were brought in to handle the water-injection work. New Jersey-based Foster Wheeler Ltd. took over as project manager. Dozens of other companies were hired to lay the pipe and build what amounted to a small oil city in the middle of the desert. The total estimated cost at the time was $6 billion.

For Mr. Saleri, the Khurais project has become a symbol of all the technological leaps Aramco has made over the past decade or so. "This will be the biggest smart field the world has ever seen," he says.

Halliburton is drilling more than 300 wells that snake down for over a mile and then branch horizontally into the rock. Each can be guided electronically to within a couple of feet of where the oil lies, using a technology known as geosteering. To flush the oil out, Halliburton is drilling 125 water-injection wells and installing dozens of electric submersible pumps.

Mr. Saleri says he also insisted that dozens of observation wells be drilled, so that sophisticated sensors could monitor what was happening below ground. http://louis5j5sheehan.blogspot.com/
Once the field is operational, reservoir engineers will be able to track it second by second from Aramco's huge command center in Dhahran, about 150 miles to the northeast.

But all this wizardry also underscores Khurais's many quirks and foibles. To counter the field's lack of internal pressure, Aramco plans to inject 2.4 million barrels of seawater a day into its underground structures, around two barrels of water for every barrel of oil it hopes to extract. By comparison, Aramco first put the mighty Ghawar under limited water injection in the 1960s before turning to large-scale seawater injection in the late 1970s.

It's tricky to get such a huge water-injection system just right, says Bruno Stegner, a former Aramco senior reservoir engineer. The water has to be filtered down to extremely tiny particles to avoid plugging the pores of the rock it's supposed to flow through. The main challenge, Mr. Stegner says, will be sustaining sufficient water pressure to push oil to the producing wells through two miles or more of Khurais's tough rock layers, far less porous than Ghawar's.

Many experts are surprised that Aramco is using submersible pumps in a field that is still young, measured by its years of actual production. Aramco began installing similar pumps to boost production at its huge offshore Safaniyah field in 2005, but only after the field had been pumping oil for decades.

"The big Middle East fields used to go on for 30 or 40 years without blinking," says Chris Skrebowski, a former Aramco oil analyst who now works for the London-based Energy Institute. Khurais's geology is different. "If Ghawar is like a big wet sponge, then Khurais is like one of those hardened sponges that are very hard to wring out," he says.

Mr. Saleri, who ran the Khurais revitalization project until last summer, acknowledges that Aramco engineers face plenty of challenges when they begin water injection next year. "When you're injecting water into the periphery" of a field, he says, "if you hit fissures in the rock and aren't managing it well, you can have water flow in and kill a well. And a dead well doesn't flow."

Mr. Saleri says the strategy is to coax as much oil as possible from Khurais over the longest possible period. Aramco now boasts some of the highest recovery rates of any oil company. In the U.S. and elsewhere, companies typically manage to extract less than 40% of the oil from a field. Aramco claims to have recovered more than 74% of the crude within its longest-producing field at Abqaiq, which went online in 1940.


"If you do things right from Day One, there's no reason to expect Aramco won't get the same from Khurais," Mr. Saleri says.

That's a big if. Aramco has suffered lately from soaring costs and increasing project delays. Through most of the 1990s, it cost Aramco around $4,000 to add one barrel of daily production capacity. A huge project called Shaybah, finished in 1997, required Aramco to run roads and pipelines deep into the country's forbidding Empty Quarter and cost around $2 billion. For that, Aramco got 500,000 barrels a day in oil-production capacity.

Some experts estimate that it now costs the company closer to $16,000 to add one additional barrel of daily production capacity. Several big projects are running behind schedule because of a shortage of steel and manpower. A project called Khursaniyah was meant to bring on 500,000 barrels of daily capacity by the end of last year, but Saudi officials now say it may not hit that target until the end of the year.

Some doubt that Khurais will reach the promised 1.2 million barrels a day of oil production or be able to sustain that level if it does. Mr. Husseini, the former Aramco head of oil exploration, who retired five years ago, says he doesn't doubt the company can extract that much at least briefly. "The question," he says, "is how long you can sustain it and at what price."









They are calling it "PagerGate." It's a sex scandal involving Detroit's Democratic Mayor Kwame Kilpatrick. It broke in January and, as details dribble out, residents are falling into a depression as deep as the one afflicting their economy.

Although there is widespread disgust at Mr. Kilpatrick, there is also growing regret that the departure of this flamboyant, 37-year-old two-term mayor will end his nascent economic reforms. Actually, Motown isn't so lucky.


The hard fact is that Mr. Kilpatrick was a false prophet under whom the city wasn't going to come back – and not just because of his vices, but his virtues as well. http://louis2j2sheehan.blogspot.com/


Mr. Kilpatrick has been dogged by scandals ever since he sauntered into office – sporting a diamond earring and "mayor" embroidered on his French-cuffs – on January 2002. He habitually used city funds like his personal bank – running up $200,000 in spa treatments and champagne, for example, early in his term. The mayor reimbursed the city for about $9,000 after the scandal broke, claiming that the rest of the charges reflected legitimate city business. The city at the time was cutting police officers, and even auditors, to plug a $250 million budget deficit.

But the latest, most spectacular scandal had its genesis at a party that supposedly took place in the mayoral mansion to celebrate Mr. Kilpatrick's election, shortly after he took office. The allegation is that Mr. Kilpatrick's wife unexpectedly stopped by the party – and took a bat to a stripper whom she found consorting with him.

The state's Republican attorney general found no evidence that the party took place. The stripper is no longer available for questioning; a few months after the alleged party she was gunned down. But two Detroit police officers launched their own probe to investigate rumors of the party, as well as other complaints that the mayor's security staff was helping arrange extramarital liaisons, including one with his then chief of staff, Christine Beatty.

The mayor summarily fired the officers, who then filed a whistleblower lawsuit. Testifying under oath during trial, Mr. Kilpatrick and Ms. Beatty categorically denied having an affair, much less firing the police officers because of it. Nonetheless, the jury returned a $6.5 million verdict for the officers.

Outraged, Mr. Kilpatrick accused the predominantly white jury of racism, and vowed to appeal. But a month later, he abruptly settled for $2 million more than the jury award.

It now seems that the reason for the about-face was that the plaintiffs confronted him with text-messages that he and Ms. Beatty had exchanged on city-issued pagers. The messages discussed their sexual encounters and the firings. In exchange for the payment, the plaintiffs signed an agreement not to reveal the existence of the messages.

The City Council, oblivious to the backroom deal, rubber-stamped the settlement. But the Detroit Free Press, not wanting to let it go so easily, mounted its own investigation – and uncovered the incriminating messages.

Now Mr. Kilpatrick is being forced to defend himself against allegations that he first committed perjury to cover up the firings, and then tried to cover up the perjury by purchasing a secret deal through taxpayer funds.

The county prosecutor – an African-American woman – has filed eight criminal charges against the mayor, each of which carries a 15-year jail sentence. But Mr. Kilpatrick responded by declaring that he is on "assignment from God," and has hired a team of high-priced lawyers – paid for, in part, by the city – to defend him.

Although few believe that Mr. Kilpatrick can – or should – hang on until the end of his term next year, there is also much worry that, without him, his economic reforms will wither. That, actually, wouldn't be such a bad thing.

Mr. Kilpatrick's entire economic revival plan rests on attracting high-profile, flashy projects. True, he has been more successful than his predecessors because of his wily ability to cut deals and push them through a dysfunctional city bureaucracy. For instance, he managed to land the contract to host the 2006 Super Bowl and convince General Motors, Compuware and, more recently, Quicken Loans Inc. to relocate their offices downtown. He also succeeded in creating three casinos, and in convincing developers to restore old, historic hotels such as the Book-Cadillac to serve the casino patrons.

Mr. Kilpatrick lured each of these projects with targeted tax breaks and subsidies. Quicken alone received $200 million. But corporate giveaways are not the stuff of an economic revival. "If anything, they put small businesses, the true drivers of the economic engine, at a competitive disadvantage," observes David Littmann, senior economist at the Mackinac Public Policy Center. http://louis0j0sheehan.blogspot.com/
As a result, he says, "Many of them either shut down or just don't open."

Indeed, every indicator of economic and civic renewal has trended in the wrong direction since Mr. Kilpatrick became mayor. There is not a single year in which Detroit's unemployment rate – currently at about 15% -- has been lower than in 2001, the year before he took office. Income tax revenues last year were $27 million less than three years ago, a testimony to the city's contracting tax base. Meanwhile, high school graduation rates are an abysmal 25%, and homicide rates an astronomical 47 per 100,000, the highest among comparably sized cities.

The lack of jobs and city services is accelerating the exodus out of Detroit. A recent study by the Southeast Michigan Council of Governments estimated that, if current trends continue, the city's population will shrink to 770,000 in seven years, from about 900,000 when Mr. Kilpatrick became mayor.

Breaking the vicious cycle of shrinking population, declining revenues and worsening city services requires not a young prince selectively handing out privileges to a chosen few. It requires an overall climate fit for business. To do that, Detroit needs to simplify its Byzantine regulations (home-businesses such as day care centers or hair-braiding salons require 70 building or equipment permits to get started), slash taxes (Detroit is the fourth highest-taxed city for a family of four making $25,000), tackle crime, and improve public schools.

These are mundane, boring tasks to which a high-roller like Mr. Kilpatrick is singularly unsuited. His departure won't guarantee Detroit's economic revival. But, if he stays, Detroit will have no reason for hope, either.


        
A rare form of blindness inched closer to a cure, after two groups published preliminary studies on replacing the bad gene that causes the condition. The results are likely to boost the prospects of gene therapy, a technique that shows promise but has yet to prove it can be used to cure many diseases.

About 2,000 people in the U.S. have Leber's congenital amaurosis No. 2, caused when a child inherits a certain flawed gene from both parents. Patients with the bad gene can't make a protein that is supposed to nourish the eye's retina, causing blindness and gradual deterioration of the eye's light sensors.

On Sunday, the New England Journal of Medicine published reports from two groups -- at the Children's Hospital of Philadelphia and at University College London -- who experimented on six blind patients by injecting good copies of the necessary gene, known as RPE65, into their eyes. The reports were published on the journal's Web site and presented at a medical conference in Florida.

Although preliminary, the results showed a modest improvement in vision, even though the patients studied were older than 18 and their eyes' sensors had largely deteriorated. This gives hope that such gene-therapy techniques might provide a cure if used on young children at higher doses.

In the U.S. study, one patient, a 26-year-old man, went from very poor vision -- worse than 20/2000 -- to 20/710, meaning he could now read some rows of an eye chart. The other two U.S. patients also improved. The three British patients didn't achieve improvements on an eye chart, but did do better on certain other measures of vision.

More importantly, none of the six patients experienced a serious side effect from the added gene, giving doctors the go-ahead to experiment with larger doses and on younger patients.

Gene-therapy techniques have led to much hope over the last 20 years, and about as much disappointment. Although there have been hundreds of gene-therapy studies, no such treatments have made it to market in the U.S. Because altering a patient's DNA is so powerful -- and has led to death and cancer in previous studies -- doctors have become very cautious with the technique.

Jean Bennett, the Philadelphia doctor who led the U.S. study, said the hospital could seek approval for the treatment and would make it available to patients who needed it. http://Louis2J2Sheehan2Esquire.US
She wasn't optimistic that a pharmaceutical company would want to sell the treatment. "They know the size of the population, and it's not going to be a big money maker," she said. http://louis-j-sheehan-esquire.us/page1.aspx

Since 2005, The Boyd Company Inc. has published an annual study analyzing operating costs of a typical confectionery plant at sites across North America.

This year, for the first time, the study includes Monterrey, Mexico.

The reason to add Monterrey is obvious, said John Boyd Jr. of the Princeton, N.J.-based consulting firm. The Hershey Co. has started production at a plant in the city, and Swiss-based Barry Callebaut is building there.

"There's a tremendous move away from the U.S., and even Canada for that matter, toward Mexico," Boyd said. "We're going to see more of that."

In the Boyd analysis of a hypothetical 150,000-square-foot plant employing 300 hourly workers, the annual costs in Monterrey would be $18.5 million.

The cost in Hershey is $30.5 million, the study found.

Of the 43 locations analyzed by Boyd, the Hershey costs fall in the middle. Monterrey is the second lowest. The lowest is in Maquiladora, near the Mexican border, at $18.1 million.

Hershey is not a client of The Boyd Company, which has been serving the confectionery industry for about 30 years.

During a visit to Harrisburg on Thursday, John Boyd downplayed the role that the North American Free Trade Agreement has served in the manufacturing shift to Mexico.

"I would argue more jobs are leaving the U.S. because of high health care costs than because of NAFTA," he said. "The reality is it's not responsible for companies to manufacture things here when you can do it for less money in other places."

Health care expenses for U.S. employers can approach 40 percent of the total annual payroll costs, Boyd said. Lowering those costs would make the U.S. more competitive, he said.

Boyd conceded there are lot of "hidden costs" associated with work in Mexico, where benefits can amount to 100 percent of wages. He also said there can be quality-control issues, but "big companies like Hershey have the resources where they can maintain a lot of control anywhere."

Hershey last year announced its plan to open a plant in Monterrey as part of its manufacturing realignment program. http://louis-j-sheehan-esquire.us/
The program is expected to generate annual savings of up to $190 million by 2010. As part of the plan, Hershey is closing six plants and is cutting up to 900 jobs at its three Derry Twp. sites.

Boyd said more Hershey jobs might be lost to Mexico in the future. "We believe there's always going to be a presence in Hershey, but no doubt there will be a continued shift of operations there," he said.

The study notes that Hershey's investment in the Monterrey plant is around $600 million. Hershey has not disclosed how much it is spending on the plant.

Boyd said it based its figure on an estimate from "one of our contacts."

Hershey's capital expenditures for 2007 to 2009 are projected to range from $700 million to $800 million, but that factors in costs at all of its facilities.

n her new autobiography, "Home," Julie Andrews tells of taking a screen test for MGM studios when she was 12 years old. "They needed to gussy me up a bit because I was so exceedingly plain," she writes. "The final determination was 'She's not photogenic enough for film.'"

J.K. Rowling's book about a boy wizard was rejected by 12 publishers before a small London house picked up "Harry Potter and the Philosopher's Stone." Decca Records turned down a contract with the Beatles, saying "We don't like their sound." Walt Disney was fired by a newspaper editor who said he "lacked imagination." Michael Jordan was cut from his high-school varsity basketball team sophomore year.
[Winston Churchill]1
See photos and read more about well-known figures who overcame setbacks

What makes some people rebound from defeats and go on to greatness while others throw in the towel? Psychologists call it "self-efficacy," the unshakable belief some people have that they have what it takes to succeed. First described by Stanford University psychologist Albert Bandura in the 1970s, self-efficacy has become a key concept in educational circles, and is being applied to health care, management, sports and seemingly intractable social problems like AIDS in developing countries. It's also a hallmark of the "positive psychology" movement now sweeping the mental-health field, which focuses on developing character strengths rather than alleviating pathologies.

Self-efficacy differs from self-esteem in that it's a judgment of specific capabilities rather than a general feeling of self-worth. "It's easy to have high self-esteem -- just aim low," says Prof. Bandura, who is still teaching at Stanford at age 82. On the other hand, he notes, there are people with high self-efficacy who "drive themselves hard but have low self-esteem because their performance always falls short of their high standards."

Still, such people succeed because they believe that persistent effort will let them succeed. In fact, if success comes too easily, some people never master the ability to learn from criticism. "  http://louis-j-sheehan.org/

  People need to learn how to manage failure so it's informational and not demoralizing," says Prof. Bandura, who signs many of his emails, "May the efficacy force be with you!" ("I've failed over and over and over again in my life. That's why I succeed," Michael Jordan has said.)

Sometimes, the rest of the world just hasn't caught up with an innovator's genius. In technology, rejection is the rule rather than the exception, Prof. Bandura says. He points out that one of the original Warner Brothers said of sound films, "Who the hell wants to hear actors talk?" Steve Jobs and Steve Wozniak were rebuffed by Atari Inc. and Hewlett-Packard Co. when they tried to sell an early Apple computer. And sometimes genius itself needs time. It took Thomas Edison 1,000 tries before he invented the light bulb. ("I didn't fail 1,000 times," he told a reporter. "The light bulb was an invention with 1,000 steps.")

Where does such determination come from? In some cases it's inborn optimism -- akin to the kind of resilience that enables some children to emerge unscathed from extreme poverty, tragedy or abuse. Self-efficacy can also be acquired by mastering a task; by modeling the behavior of others who have succeeded; and from what Prof. Bandura calls "verbal persuasion" -- getting effective encouragement that is tied to achievement, rather than empty praise.

"I teach teachers here, and one of the things we teach them is how to build up children who have been told they aren't competent," says Frank Pajares, a professor of education at Emory University who has been a leader in using self-efficacy to nurture academic confidence. "We all have mental habits, and once they are set, they are as hard to break as stopping smoking or biting your fingernails."

It's not too late to recover. "You can develop a resilient mindset at any age," says Robert Brooks, a Harvard Medical School psychologist who has studied resilience for decades. One key, he says, is to avoid self-defeating assumptions. If you are fired or dumped by a girlfriend, don't magnify the rejection and assume you'll never get another job or another date. (Maintaining perspective can be tough in the face of sweeping criticism, though. A teacher said of young G.K. Chesteron, who went on to become a renowned British author, that if his head were opened "we should not find any brain but only a lump of white fat.")

And don't allow a rejection to derail your dreams. "One of the greatest impediments to life is the fear of humiliation," says Prof. Brooks, who says he's worked with people who have spent the last 30 years of their lives not taking any risks or challenges because they are afraid of making mistakes.

What if you really do lack the talent to succeed at whatever you're trying to do? That's a tricky question, psychologists say -- one that's on display in the early episodes of "American Idol" each season. Try to objectively assess how much you are likely to improve with training and hard work, and how much it's worth to you, or whether there are other ways to enjoy your passion -- being a coach instead of a player, for instance. On the other hand, what if Dr. Seuss had given up after his 27th rejection and not tried once more? In the words of Henry Ford: "Whether you think that you can or you can't, you're usually right."



Laughing Genes by Evan Louis Sheehan



The Laughing Genes: A Scientific Perspective on Ethics and Morality
by Evan Louis Sheehan

Metaphorically, our genes might chuckle at how we humans unwittingly define our morality to serve their interests, even above our own. http://louis-j-sheehan.info/
By our dearly sacrificing for our children, we clearly show that our moral intuitions serve the interests of our genes. While we each seem to willfully pursue different methods for getting the things we want, the fundamental things we want - fit sexual partners, and well-being for ourselves and our children - are not defined by our wills, but rather, by our genes. From a unique, irreverent, yet fully scientific perspective, this book clearly explains the philosophical mysteries of life, God, intellectual creativity, feelings of consciousness, the meaning of responsibility in a world full of deterministic minds, and especially, morality.

        
    * The Mocking Memes: A Basis for Automated Intelligence by Evan Louis Sheehan in Back Matter



          
        

        

At last, a bible for philosophers and social thinkers who hold a scientific perspective of reality and man! "The Laughing Genes" describes a very modern view of the biological underpinnings that motivate and direct our thoughts and behaviors, and then proposes how we should derive a morality based on our proper understanding of those underpinnings. Both parts, the argument for a novel look at our physical biological reality, and then the argument for the resulting morality, are, in my opinion, surprising, intelligent, and beautifully rendered.

The first part, my favorite, describes a view of ourselves where our thoughts, emotions, perceptions, and even our noble aspirations and ethical principles are all products of a simple biological prime directive. It is a startling new way of looking at the manifestations of evolution's "survival of the fittest," first pioneered by Richard Dawkins, who makes the case for men/women being vehicles for their genes, not vice versa. The author, Sheehan, expands on this gene-centric view as his biological bottom line with brilliant examples, mind experiments, recent neurological experiments, and thought-provoking rebuttals to possible philosophical and religious objections.

It goes far beyond biology! That's just the starting point. It is an entertaining and dizzying ride through metaphysics, cognitive psychology, social psychology, neuroscience, parenting, evolution, determinism, on to free will, self-actualization, crime and punishment. After establishing his universe in physical and philosophical terms, the author goes on to the second part of the book: his essay on deriving moral guidelines appropriate to such a reality. These guidelines will surprise you. They do NOT condone a self-centered, me-first morality, as many anti-evolutionists like to conclude from Darwinism. The book is a carefully guided journey to these guidelines, revealed toward the end, so I will not give away anything here; suffice it to say even if you don't support the moral conclusions, you will learn from the ride and enjoy getting there.

I particuliarly enjoyed the author's style of writing. He balances philosophy with day to day perceptions and experiences. After stating each point, the author gives
brilliant examples and conceptual clarifications to illustrate the point. He also anticipates the reader's reactions and addresses them, along with some reactions this reader hadn't thought of. He is not stuffy or dry.

The author knows his material. I love this stuff, and I'm reasonably well read in several of the disciplines that he touches upon. Nonetheless, I was exposed to several new concepts ("memes" for example),new scientific experiments (the research on consciousness is eye opening), and new ways of reflecting on right/wrong. I agreed with his metaphysics, in fact I was in awe of his ability to describe and defend them, better than I could. I am still digesting his discourse on fairness, efficiency, and ethics, and for the most part, reluctantly agreeing. Whether or not you buy his metaphysics or his morality, you will find this book well written and a stimulating read.
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6 of 6 people found the following review helpful:
5.0 out of 5 stars The Meaning and Purpose of Life, November 30, 2005
By      Mark Martin "-- Evolutionary Revolutionary --" (Newark, Delaware USA) - See all my reviews
(REAL NAME)  
If you want to know why evolution programmed humans to have moral feelings of loyalty, compassion, gratitude, friendship and love, then this is the book for you.

If you want to understand evolution's inevitable goal for all advanced life (to practice a benevolent style of morality based on cooperation), then this is the book for you.

If you want to know why we are perfectly entitled to derive 'ought' from 'is' ..., if you want to fully understand the debate over determinism and free will ..., if you want to learn why evolution needed to develop human emotions and feelings of consciousness ..., if you want to understand the meaning of life, then this is the book for you.

This is the logical sequel to Richard Dawkins's book, "The Selfish Gene." By carrying on the perspective of the gene's-eye-view, this book reconciles evolution with human feelings, human will and human morality. It succeeds where Daniel Dennett's books fall short, by providing a clear prescription for living a purposeful and moral life.

The subjects in this book are deep, but the writing is clear and concise. The investment of time to read it is not insignificant, but the reading is easy and the payoff is enormous, whether or not you agree with the conclusions.

Buy it, read it and see for yourself. The world would be a much better place if everyone did.








The Mocking Memes: A Basis for Automated Intelligence (Paperback)
by Evan Louis Sheehan

All scientific evidence supports the astonishing hypothesis that minds are brains and brains are biological machines. But, then, what sort of neural architecture accounts for the human ability to think? The answer logically follows from another astonishing hypothesis: There is no source of creativity anywhere in the universe other than the process of evolution. Such is the simple premise on which this book's description of all intelligence is based. Human thinking is thus reduced to a mechanistic process of neural firing patterns evolving. In this unique yet simple model of mind, memes are the currency of creative thought. All sorts of intelligence, from the creation of the universe all the way down to human thoughts, are explained as evolving patterns.
Product Details


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    * Paperback: 332 pages
    * Publisher: AuthorHouse (October 11, 2006)
    * Language: English
    * ISBN-10: 1425961606
    * ISBN-13: 978-1425961602
    * Product Dimensions: 8.9 x 6 x 1 inches
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Although the ancient Roman holiday of Floralia, celebrated by the set of games and theatrical presentations known as the Ludi Florales, began in April, it was really an ancient May Day celebration. Flora, the Roman goddess in whose honor the festival was held, was a goddess of flowers, which generally begin to bloom in the spring. The holiday for Flora (as officially determined by Julius Caesar when he fixed the Roman calendar) ran from April 28 to May 3.

Roman public games (ludi) were financed by minor public magistrates known as aediles. The curule aediles produced the Ludi Florales. The position of curule aedile was originally (365 B.C.) limited to patricians, but was later opened up to plebeians. The ludi could be very expensive for the aediles, who used the games as a way of winning the affection and votes of the people. In this way, the aediles hoped to ensure victory in future elections for higher office after they had finished their year as aediles.

The Floralia festival began in Rome in 238 B.C., to please the goddess Flora into protecting the blossoms. http://www.myface.com/index.php?do=/public/account/submit/add-blog/added_3049/
The Floralia fell out of favor and was discontinued until 173 B.C., when the senate, concerned with wind, hail, and other damage to the flowers, ordered Flora's celebration reinstated as the Ludi Florales.

The Ludi Florales included theatrical entertainment, including mimes, naked actresses and prostitutes. In the Renaissance, some writers thought that Flora had been a human prostitute who was turned into a goddess, possibly because of the licentiousness of the Ludi Florales or because, according to) David Lupher, Flora was a common name for prostitutes in ancient Rome.

The celebration in honor of Flora included floral wreaths worn in the hair much like modern participants in May Day celebrations. After the theatrical performances, the celebration continued in the Circus Maximus, where animals were set free and beans scattered to insure fertility.







I. Of my grandfather Verus I have learned to be gentle and meek, and to refrain from all anger and passion. From the fame and memory of him that begot me I have learned both shamefastness and manlike behaviour. Of my mother I have learned to be religious, and bountiful; and to forbear, not only to do, but to intend any evil; to content myself with a spare diet, and to fly all such excess as is incidental to great wealth. Of my great-grandfather, both to frequent public schools and auditories, and to get me good and able teachers at home; and that I ought not to think much, if upon such occasions, I were at excessive charges.